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KMID : 0613820080180101342
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Journal of Life Science
2008 Volume.18 No. 10 p.1342 ~ p.1347
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Effect of Silkworm (Bombyx mori) Excrement Powder on the Alcoholic Hepatotoxicity in Rats
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Kim Yong-Soon
Kim Kee-Young
Kang Pil-Don
Cha Jae-Young
Heo Jin-Sun
Park Bo-Kyung
Cho Young-Su
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Abstract
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The purpose of present study was to investigate the protective effect of silkworm excrement powder (SEP) on alcohol-induced hepatotoxicity in rats. Semisynthetic diet supplemented with SEP (3%, w/w) given to alcohol-feeding rats for 30 days, then blood and tissues were collected, processed and used for alcohol concentration mensuration, various biochemical estimations and histopathological examination. Chronic alcohol administration resulted in significantly increase in the activities of the clinically important liver marker enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (γ-GTP) and lactate dehydrogenase (LDH). Also, a highly significant
increase in the blood alcohol level by alcohol treatment was observed. But alcohol-induced elevation of ALT and LDH levels markedly prevented and the level of blood alcohol decreased in SEP treated rats as compared to alcohol-administered control rats. SEP supplementation showed highly decreased the concentrations of total lipid, triglyceride and cholesterol in serum, as compared with alcohol treated control rats. Alcohol treatment induced the marked accumulation of large lipid droplets, hepatocytes necrosis and inflammation in the liver, but SEP administration attenuated to alcohol-induced accumulation of lipid droplets and hepatocyte necrosis. The results indicated that SEP may exert a protective effect against alcoholic hepatotoxicity through decreasing the activity of hepatic marker enzymes.
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KEYWORD
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Silkworm excrement powder (SEP), alcohol, hepatotoxicity, rat
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